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Catalog# Product Description |
ICP9810 Affinity purified rabbit polyclonal p44 MAPK antibody is developed using the C-terminal peptide of human MAPK (ERK1). |
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Western blot analysis of mouse brain extract (B) and spleen extract (A) with ICP9810.
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Species
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Rabbit
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Formulation
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250 μg/mL in TBS, 50% glycerol, 0.01% NaN3
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Immunogen
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Human p44 ERK1 C-terminal peptide-KLH conjugates
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Purification
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The antibody was affinity purified with the p44 ERK1 C-terminal peptide on agarose.
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Specificity
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The antibody recognizes p44 ERK1 of human, rat, bovine, mouse and rabbit. There is a slight cross reaction with p42 ERK2.
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Applications
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ELISA; WB; IP
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Scientific Description
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One of the members of mitogen-activated protein kinases is called P44 MAP Kinase (Erk1). It participates in cell growth and differentiation. [1,2] By phosphorylating transcription factors, (e., ELK-1), P44 MAP kinase regulates meiosis and mitosis of the cell. In the case of human MAP kinase, Erk1 activates Elk-1 through phosphorylation of threonine 202 and tyrosine 204. It is also known that Erk1 autophosphorylates tyrosine. [3]
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Storage & Stability
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Product is stable for several weeks at 4°C. For extended storage, store product at -20°C. Expiration date is one year from date of shipping if stored properly.
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Product Specific References |
1. Mol Cell Biol. 1993.13: 4679–4690. doi:10.1128/MCB.13.8.4679 2. Cell. 1995. 80: 179–185. doi:10.1016/0092-8674(95)90401-8 3. EMBO J. 1991. 10: 885–892. |
